Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels

Autor: Jinsheng Zhou, Yanqian Wang, Laurent D. Menard, Sergey Panyukov, Michael Rubinstein, J. Michael Ramsey
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00951-4
Popis: Forcing a DNA molecule into a nanoscale channel requires overcoming the free energy barrier associated with confinement. Here, the authors show that DNA injected through a funnel-shaped entrance more efficiently enters the nanochannel, thanks to facilitating forces generated by the nanofunnel geometry.
Databáze: Directory of Open Access Journals