| Autor: |
Congsun Li, Jie Wang, Weinan Yang, Kang Yu, Jianqiao Hong, Xiaoxiao Ji, Minjun Yao, Sihao Li, Jinwei Lu, Yazhou Chen, Shigui Yan, Haobo Wu, Chiyuan Ma, Xiaohua Yu, Guangyao Jiang, An Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-14 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1477-3155 |
| DOI: |
10.1186/s12951-023-01892-5 |
| Popis: |
Abstract Long-term chronic inflammation after Achilles tendon injury is critical for tendinopathy. Platelet-rich plasma (PRP) injection, which is a common method for treating tendinopathy, has positive effects on tendon repair. In addition, tendon-derived stem cells (TDSCs), which are stem cells located in tendons, play a major role in maintaining tissue homeostasis and postinjury repair. In this study, injectable gelatine methacryloyl (GelMA) microparticles containing PRP laden with TDSCs (PRP–TDSC–GM) were prepared by a projection-based 3D bioprinting technique. Our results showed that PRP–TDSC–GM could promote tendon differentiation in TDSCs and reduce the inflammatory response by downregulating the PI3K–AKT pathway, thus promoting the structural and functional repair of tendons in vivo. Graphical Abstract |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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