Nitrofuran antibiotics: a review on the application, prohibition and residual analysis

Autor:	M. Vass, K. Hruska, M. Franek
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	nitrofurans tissue bound metabolites semicarbazide bioavailability mutagenicity legislation sample preparation validation detection methods Veterinary medicine SF600-1100
Zdroj:	Veterinární Medicína, Vol 53, Iss 9, Pp 469-500 (2008)
Druh dokumentu:	article
ISSN:	0375-8427 1805-9392
DOI:	10.17221/1979-VETMED
Popis:	Nitrofuran antibiotics, employed for the treatment of bacterial diseases in livestock production, were banned from use in the European Union (EU) in 1995 due to concerns about the carcinogenicity of their residues in edible tissue. This review provides an overview of nitrofuran toxicity, metabolism, and also specific aspects of legislation surrounding their prohibition. Special attention is devoted to semicarbazide - a nitrofuran metabolite and food contaminant. Analytical procedures for nitrofuran analysis in various matrices and validation requirements for screening and confirmation methods with respect to EU regulations are also reviewed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/90dd338918e340b09cd34657c0d2c1f6 Zobrazit plný text záznamu View record in DOAJ