Advances research in porcine enteric coronavirus therapies and antiviral drugs
| Autor: | Jixiang Liang, Weihang Xu, Xiaoming Pan, Shiyun Han, Linwei Zhang, Hao Wen, Mingyue Ding, Wanpo Zhang, Dapeng Peng |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Veterinary Quarterly, Vol 44, Iss 1, Pp 1-49 (2024) |
| Druh dokumentu: | article |
| ISSN: | 01652176 1875-5941 0165-2176 |
| DOI: | 10.1080/01652176.2024.2421299 |
| Popis: | The porcine enteric coronaviruses (PECs) currently reported include porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV). In the absence of effective treatment, they can cause similar clinical characteristics including weight loss, sleepiness, vomiting, anorexia and fatal diarrhea in neonatal piglets, resulting in significant economic losses to the global pig industry. Although many studies on drugs for treating and combating PECs have been issued. There are still no specific drug targeting PECs and used in clinical production. Therefore, it is necessary to sort out and summarize the research on the treatment and anti PECs drugs, and further development of low toxicity and high efficiency drugs is needed. Here, we review the latest progress of anti PECs drugs, focus on the mechanism of anti PECs reaction of drug components, and try to clarify new strategies for effective control and elimination of PECs. These comprehensive and profound insights will help to further investigate, prevent and control the transmission of PECs infection. |
| Databáze: | Directory of Open Access Journals |
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