Autor: |
Nathalie Verónica Fernández Villalobos, Patrick Marsall, Johanna Carolina Torres Páez, Julia Strömpl, Jens Gruber, Martín Lotto Batista, Daria Pohl, Gustavo Concha, Hagen Frickmann, Fernando Pio de la Hoz Restrepo, Nicole Schneiderhan-Marra, Gérard Krause, Alex Dulovic, Monika Strengert, Simone Kann |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Communications Medicine, Vol 3, Iss 1, Pp 1-8 (2023) |
Druh dokumentu: |
article |
ISSN: |
2730-664X |
DOI: |
10.1038/s43856-023-00376-9 |
Popis: |
Abstract Background Although anti-SARS-CoV-2 humoral immune responses and epidemiology have been extensively studied, data gaps remain for certain populations such as indigenous people or children especially in low- and middle-income countries. To address this gap, we evaluated SARS-CoV-2 seroprevalence and humoral immunity towards the parental B.1 strain, local SARS-CoV-2 variants, and endemic coronaviruses in children from Colombia from March to April 2021. Methods We performed a cross-sectional seroprevalence study with 80 children from Bogotá and expanded our analysis by comparing results with an independent observational study of 82 children from the Wiwa community living in the north-eastern Colombian territories. Antibody IgG titers towards SARS-CoV-2 and the endemic coronaviruses as well as ACE2 binding inhibition as a proxy for neutralization towards several SARS-CoV-2 variants were analyzed using two multiplex-based immunoassays. Results While we find seroprevalence estimates of 21.3% in children from Bogotá, seroprevalence is higher with 34.1% in Wiwa children. We observe a robust induction of antibodies towards the surface-exposed spike protein, its S1-, S2- and receptor-binding-subdomains in all SARS-CoV-2 seropositive children. Only nucleocapsid-specific IgG is significantly lower in the indigenous participants. ACE2 binding inhibition is low for all SARS-CoV-2 variants examined. We observe a dominance of NL63 S1 IgG levels in urban and indigenous children which suggests an early exposure to this respiratory virus independent of living conditions and geographic location. SARS-CoV-2 seropositivity does not correlate with antibody levels towards any of the four endemic coronaviruses indicating the absence of cross-protective immunity. Conclusions Overall, antibody titers, but in particular ACE2 binding inhibition are low within Colombian samples, requiring further investigation to determine any potential clinical significance. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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