| Autor: |
Joon Park, Eun Yeong Lim, Yun Tai Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 85, Iss , Pp 104659- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2021.104659 |
| Popis: |
This study investigated the inhibitory effect and underlying mechanisms of Aster yomena extract (AYE) on microglial activation-mediated inflammatory pain. Lipopolysaccharide (LPS)-induced microglial activation exhibited increased expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokines. LPS-induced microglial activation was suppressed by AYE treatment via inhibition of the NF-κB and MAPK signaling pathways. To investigate the protective effects of AYE on inflammatory pain, complete Freund’s adjuvant (CFA) was injected into the right paw of mice. Pain hypersensitivity and microglial activation in the spinal cord were markedly alleviated by oral administration of AYE. HPLC was performed and identified chlorogenic acid (CGA) and t-Ferulic acid (FRA) as the major active components in AYE. Both components showed inhibitory effects on LPS-induced microglial activation in BV2 cells. Our study demonstrates that AYE inhibits microglial activation-mediated inflammatory pain and that AYE has potential application as a natural analgesic. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full Text from ScienceDirect