| Autor: |
Custer C. Deocaris, Malona V. Alinsug |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Tropical Life Science, Vol 11, Iss 1, Pp 53-57 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2087-5517 |
| DOI: |
10.11594/jtls.11.01.07 |
| Popis: |
There isaccumulating evidence suggesting that ACE2, the host cell receptor for the spike (S) protein of the SARS-CoV-2, mediates viral entry and infection, is under epigenetic control. Here, we discuss studies suggesting a nutritional strategy for down-regulating ACE2 expression in tissues of offspring through the phenom-enon of maternal epigenomic reprogramming mediated by maternal diet. The "thrifty hypothesis" was first proposed by Hales and Barker,which posits that spe-cific genes are programmed based on early-life experience to promote efficient fat deposition and storage in adulthood. Our analysis of the proposed mechanism for "early life programming" in this paper vianutritional modulation of histone acety-lation and DNA methylation goes beyond the physiological consequence of boost-ing the innate cellular resistance to a viral transmission. During the pandemic,where there is still no specific antiviral drug or a widely disseminated vaccine for COVID-19, we hypothesize that an epigenomic nutritionapproachmay be a prac-tical approach to help mitigate viral transmission offspring. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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