| Autor: |
Peter Ikechukwu Emmanuel, Ugwu Chikamso Sandra, Onwuka Akachukwu Marytheresa, Mbaoji Florence Nwakaego, Ofokansi Martha Nneoma, Onyeto Collins Azubuike, Philip F. Uzor |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Future Journal of Pharmaceutical Sciences, Vol 8, Iss 1, Pp 1-11 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2314-7253 |
| DOI: |
10.1186/s43094-022-00442-4 |
| Popis: |
Abstract Background Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to treat ulcers and gastrointestinal disorders, including distended spleens and the liver. This study investigated the gastroprotective effects of C. paniculatum leaf extract and its fractions on absolute ethanol-induced gastric ulcers in rats and explored their effects on endogenous antioxidant (SOD, MDA, GSH, and Catalase) levels. Butanol, n-hexane, and ethyl acetate extracts (100 and 200 mg/kg), omeprazole (20 mg/kg), and control (3% Tween 80) were administered orally. Results The methanolic extract and fractions of C. paniculatum exhibited varying degrees of ulcer protection. MECP exhibited significant (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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