The effect of Cinnamomum zeylanicum bark water extract on memory performance in alloxan-induced diabetic mice
| Autor: | Azadeh Mesripour, Fatemeh Moghimi, Mahmoud Rafieian-Kopaie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Research in Pharmaceutical Sciences, Vol 11, Iss 4, Pp 318-323 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1735-5362 1735-9414 |
| DOI: | 10.4103/1735-5362.189308 |
| Popis: | Cinnamomum zeylanicum (cinnamon) has a wide range of beneficial effects including mild glucose lowering activity. The aim of the present study was to investigate whether cinnamon bark extract has the potential to improve memory performance and glucose profiles in diabetic mice. Memory was assessed by the novel object recognition task in male Balb/c mice. In this method, the difference between exploration time of a familiar object and a novel object was considered as an index of memory performance (recognition index, RI). The water extract was prepared by boiling cinnamon bark for 15 min. Alloxan induced diabetes in animals (serum glucose levels were 322 ± 7.5 mg/dL), and also impaired memory performance (RI= -3.3% ± 3.3) which differed significantly from control animals (RI = 32% ± 6.5). Although treatment with cinnamon only reduced fasting blood glucose level moderately but it improved memory performance remarkably (RI = 25.5% ± 5.6). Oxidative stress following administration of cinnamon extract was lower in diabetic mice. It was concluded that cinnamon water extract could be a useful alternative medicine in diabetic patients′ daily regimen which not only reduces blood glucose levels but also improves memory performance and lipid peroxidation level. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|