Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts

Autor: Sheila K. Patel, Bryan Wai, Chim C. Lang, Daniel Levin, Colin N.A. Palmer, Helen M. Parry, Elena Velkoska, Stephen B. Harrap, Piyush M. Srivastava, Louise M. Burrell
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: EBioMedicine, Vol 18, Iss C, Pp 171-178 (2017)
Druh dokumentu: article
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2017.03.036
Popis: Left ventricular (LV) hypertrophy (LVH) is a heritable trait that is common in type 2 diabetes and is associated with the development of heart failure. The transcriptional factor Kruppel like factor 15 (KLF15) is expressed in the heart and acts as a repressor of cardiac hypertrophy in experimental models. This study investigated if KLF15 gene variants were associated with LVH in type 2 diabetes. In stage 1 of a 2-stage approach, patients with type 2 diabetes and no known cardiac disease were prospectively recruited for a transthoracic echocardiographic assessment (Melbourne Diabetes Heart Cohort) (n = 318) and genotyping of two KLF15 single nucleotide polymorphisms (SNPs) (rs9838915, rs6796325). In stage 2, the association of KLF15 SNPs with LVH was investigated in the Genetics of Diabetes Audit and Research in Tayside Scotland (Go-DARTS) type 2 diabetes cohort (n = 5631). The KLF15 SNP rs9838915 A allele was associated in a dominant manner with LV mass before (P = 0.003) and after (P = 0.001) adjustment for age, gender, body mass index (BMI) and hypertension, and with adjusted septal (P
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