Identification of a ZC3H12D-regulated competing endogenous RNA network for prognosis of lung adenocarcinoma at single-cell level

Autor:	Wenhan Chen, Zhifeng Guo, Jingyang Wu, Guofu Lin, Shaohua Chen, Qinhui Lin, Jiansheng Yang, Yuan Xu, Yiming Zeng
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Zinc finger CCCH-type containing 12D (ZC3H12D) Competitive endogenous RNA Single-cell RNA sequencing Lung adenocarcinoma Immunomics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 22, Iss 1, Pp 1-17 (2022)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-021-08992-1
Popis:	Abstract Background To identify hub genes from the competing endogenous RNA (ceRNA) network of lung adenocarcinoma (LUAD) and to explore their potential functions on prognosis of patients from a single-cell perspective. Methods We performed RNA-sequencing of LUAD to construct ceRNA regulatory network, integrating with public databases to identify the vital pathways related to patients’ prognosis and to reveal the expression level of hub genes under different conditions, the functional enrichment of co-expressed genes and their potential immune-related mechanisms. Results ZC3H12D-hsa-miR-4443-ENST00000630242 axis was found to be related with LUAD. Lower ZC3H12D expression was significantly associated with shorter overall survival (OS) of patients (HR = 2.007, P
Databáze:	Directory of Open Access Journals
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