| Autor: |
Meiyu Chen, Jie Liu, Wei Qin, Qian Wang, Ri Zhang, Hongying Chao |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Leukemia Research Reports, Vol 11, Iss , Pp 24-26 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2213-0489 |
| DOI: |
10.1016/j.lrr.2019.04.002 |
| Popis: |
The natural history of primary hypereosinophilia remains poorly defined, given the underlying disease heterogeneity. Recently, targeted NGS helps to establish clonality in a subset of patients with hypereosinophilia. We first reported the clonal evolution in a long-term follow-up patient with hypereosinophilia. This case initially presented with chronic eosinophilic leukemia, not otherwise specified (CEL-NOS), successively transformed to myelodysplastic syndromes (MDS) and acute myeloid leukemia(s-AML). We identified three mutations at CEL-NOS phase, five and seven mutations at MDS and s-AML stages, respectively. Our data illustrate the clonal dynamic process associated with disease evolution from CEL-NOS to s-AML. Keywords: Hypereosinophilia, Clonal evolution, Next generation sequencing |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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