| Autor: |
David A. Jaques, Edward Pivin, Menno Pruijm, Daniel Ackermann, Idris Guessous, Georg Ehret, Fang‐Fei Wei, Jan A. Staessen, Antoinette Pechère‐Bertschi, Cees Vermeer, Bruno Vogt, Michel Burnier, Pierre‐Yves Martin, Murielle Bochud, Belen Ponte |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 18 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.119.013558 |
| Popis: |
Background Increased renal resistive index (RRI) has been associated with target organ damage as well as renal and cardiovascular outcomes. Matrix Gla (γ‐carboxyglutamate) protein (MGP) is a strong inhibitor of soft tissue calcification. Its inactive form (dephospho‐uncarboxylated MGP [dp‐ucMGP]) has been associated with vascular stiffness, cardiovascular outcomes, and mortality. In this study, we hypothesized that high levels of dp‐ucMGP were associated with increased RRI. Methods and Results We recruited participants via a multicenter family‐based cross‐sectional study in Switzerland. Levels of dp‐ucMGP were measured in plasma by sandwich ELISA. RRI was measured by Doppler ultrasound in 3 segmental arteries in both kidneys. We used mixed regression models to assess the relationship between dp‐ucMGP and RRI. We adjusted for common determinants of RRI as well as renal function and cardiovascular risk factors. We included 1006 participants in our analyses: 526 women and 480 men. Mean values were 0.44±0.20 nmol/L for dp‐ucMGP and 64±5% for RRI. After multivariable adjustment, dp‐ucMGP was positively associated with RRI (P=0.001). In subgroup analysis by age tertiles, this association was not significant in the youngest age group (55 years; P=0.016 and P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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