| Autor: |
Abbas F. Almulla, Yanin Thipakorn, Asara Vasupanrajit, Ali Abbas Abo Algon, Chavit Tunvirachaisakul, Ashwan Abdulzahra Hashim Aljanabi, Gregory Oxenkrug, Hussein K. Al-Hakeim, Michael Maes |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Brain, Behavior, & Immunity - Health, Vol 26, Iss , Pp 100537- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3546 |
| DOI: |
10.1016/j.bbih.2022.100537 |
| Popis: |
Background: There is now evidence that affective disorders including major depressive disorder (MDD) and bipolar disorder (BD) are mediated by immune-inflammatory and nitro-oxidative pathways. Activation of these pathways may be associated with activation of the tryptophan catabolite (TRYCAT) pathway by inducing indoleamine 2,3-dioxygenase (IDO, the rate-limiting enzyme) leading to depletion of tryptophan (TRP) and increases in tryptophan catabolites (TRYCATs). Aims: To systematically review and meta-analyze central and peripheral (free and total) TRP levels, its competing amino-acids (CAAs) and TRYCATs in MDD and BD. Methods: This review searched PubMed, Google Scholar and SciFinder and included 121 full-text articles and 15470 individuals, including 8024 MDD/BD patients and 7446 healthy controls. Results: TRP levels (either free and total) and the TRP/CAAs ratio were significantly decreased (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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