The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway

Autor: Ling Wang, Mary E. A. Howell, Ayrianna Sparks-Wallace, Juan Zhao, Culton R. Hensley, Camri A. Nicksic, Shanna R. Horne, Kaylea B. Mohr, Jonathan P. Moorman, Zhi Q. Yao, Shunbin Ning
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: mBio, Vol 12, Iss 5 (2021)
Druh dokumentu: article
ISSN: 2150-7511
DOI: 10.1128/mBio.01097-21
Popis: As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.
Databáze: Directory of Open Access Journals