Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect
| Autor: | Lilian Martins Oliveira Diniz, Tiago Guimarães, Maria das Graças Rodrigues de Oliveira, Jorge Andrade Pinto, Silvana Spindola de Miranda |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Jornal Brasileiro de Pneumologia, Vol 40, Iss 2, Pp 188-192 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1806-3756 1806-3713 |
| DOI: | 10.1590/S1806-37132014000200014 |
| Popis: | We report a rare case in a female infant (age, 3.5 months) with primary immunodeficiency (IFN-γ/IL-12 pathway defect) who presented with suppurative lymphadenitis after Mycobacterium bovis BCG vaccination. The strain of M. bovis BCG identified was found to be resistant to isoniazid and rifampin. The patient was treated with a special pharmacological regimen involving isoniazid (in a limited, strategic manner), ethambutol, streptomycin, and IFN-γ, after which there was complete resolution of the lesions. |
| Databáze: | Directory of Open Access Journals |
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