Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats
| Autor: | F.A.C. Seara, I.G. Araujo, G.E. Império, M.P. Marassi, A.C.M. Silva, A.S. Mecawi, L.C. Reis, E.L. Olivares |
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| Jazyk: | angličtina |
| Předmět: | |
| Zdroj: | Brazilian Journal of Medical and Biological Research |
| Druh dokumentu: | article |
| ISSN: | 1414-431X 1414-431x |
| DOI: | 10.1590/1414-431x20198491 |
| Popis: | Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which would then constitute a possible target for β-adrenergic blocking agents in a myocardial infarction (MI) model induced by left coronary occlusion in rats. Despite a sustained and dramatic fall in serum T4 concentrations (60–70%), the serum T3 concentration fell only transiently in the first week post-infarction (53%) and returned to control levels at 8 and 12 weeks after surgery compared to the Sham group (P |
| Databáze: | Directory of Open Access Journals |
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