DETERMINATION OF ELEMENTAL IMPURITIES IN SOME COMMERCIAL PAEDIATRIC AND ADULT FORMULATIONS OF ARTEMETHER – LUMEFANTRINE IN THE NIGERIAN MARKET BY ATOMIC ABSORPTION SPECTROSCOPY
| Autor: | Sunday O. Awofisayo, Augustine O. Okhamafe, Mathew I. Arhewoh |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Indonesian Journal of Pharmacy, Vol 26, Iss 3, Pp 171-176 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2338-9427 2338-9486 |
| DOI: | 10.14499/indonesianjpharm26iss3pp171 |
| Popis: | The composition of elemental impurities in paediatric powder for suspension (PPS) and double strength tablet (DST) commercial anti-malarial formulations of artemether-lumefantrine (AL) were determined. Six randomly selected PPS and DST products from a list of marketed products were purchased from a registered Pharmacy outlet and analyzed using flame atomic absorption spectrophotometer. The heavy metal levels were compared with the official limits for permitted daily exposure. The paediatric and adult products of AL presented the same types and number of elements with a total of 10 metals and levels ranging from 0.001-0.016 and 0.001-0.017ppm for the PPS and DST formulation, respectively. One of the DST and PPS products had significantly higher levels of cadmium, copper, chromium, nickel and cobalt compared with their respective formulation types (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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