Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets
| Autor: | Micheli Wrasse-Sangoi, Leonardo Trevisan Secretti, Isabel Fração Diefenbach, Clarice Madalena Bueno Rolim, Maximiliano da Silva Sangoi |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 33, Iss 6, Pp 1330-1334 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0100-4042 1678-7064 |
| DOI: | 10.1590/S0100-40422010000600021 |
| Popis: | For determination of aliskiren in commercial samples, an analytical UV spectrophotometric method was developed and validate according to ICH guideline. The method was linear in the range between 40 and 100 μg mL-1 (r² = 0.9997, n = 7) and exhibited suitable specificity, accuracy, precision, and robustness. It is simple, it has low cost, and it has low use polluting reagents. Therefore, the proposed method was successfully applied for the assay and dissolution studies of aliskiren in tablet dosage forms, and the results were compared to a validated RP-LC method, showing non-significant difference (P > 0.05). |
| Databáze: | Directory of Open Access Journals |
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