Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression

Autor: Guilhem Carle, Mehdi Touat, Nicolas Bruno, Damien Galanaud, Charles-Siegfried Peretti, Antoni Valero-Cabré, Richard Levy, Carole Azuar
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Frontiers in Psychiatry, Vol 8 (2017)
Druh dokumentu: article
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2017.00096
Popis: The potential of repetitive transcranial magnetic stimulation (rTMS) to treat numerous neurological and psychiatric disorders has been thoroughly studied for the last two decades. Here, we report for the first time, the case of a 65-year-old woman suffering from treatment-resistant depression who developed an acute frontal lobe syndrome following eight sessions of low-frequency rTMS (LF-rTMS) to the right dorsolateral prefrontal cortex while also treated with sertraline and mianserin. The pathophysiological mechanisms underlying such an unexpected acute frontal lobe dysfunction are discussed in relation to the therapeutic use of LF-rTMS in combination with pharmacotherapy in depressed patients.
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