| Autor: |
Samia C Akhter-Khan, Qiushan Tao, Ting Fang Alvin Ang, Cody Karjadi, Indira Swetha Itchapurapu, David J Libon, Michael Alosco, Jesse Mez, Wei Qiao Qiu, Rhoda Au |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Medical Internet Research, Vol 26, p e45780 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1438-8871 |
| DOI: |
10.2196/45780 |
| Popis: |
BackgroundCerebral microbleeds (CMB) increase the risk for Alzheimer disease. Current neuroimaging methods that are used to detect CMB are costly and not always accessible. ObjectiveThis study aimed to explore whether the digital clock-drawing test (DCT) may provide a behavioral indicator of CMB. MethodsIn this study, we analyzed data from participants in the Framingham Heart Study offspring cohort who underwent both brain magnetic resonance imaging scans (Siemens 1.5T, Siemens Healthcare Private Limited; T2*-GRE weighted sequences) for CMB diagnosis and the DCT as a predictor. Additionally, paper-based clock-drawing tests were also collected during the DCT. Individuals with a history of dementia or stroke were excluded. Robust multivariable linear regression models were used to examine the association between DCT facet scores with CMB prevalence, adjusting for relevant covariates. Receiver operating characteristic (ROC) curve analyses were used to evaluate DCT facet scores as predictors of CMB prevalence. Sensitivity analyses were conducted by further including participants with stroke and dementia. ResultsThe study sample consisted of 1020 (n=585, 57.35% female) individuals aged 45 years and older (mean 72, SD 7.9 years). Among them, 64 (6.27%) participants exhibited CMB, comprising 46 with lobar-only, 11 with deep-only, and 7 with mixed (lobar+deep) CMB. Individuals with CMB tended to be older and had a higher prevalence of mild cognitive impairment and higher white matter hyperintensities compared to those without CMB (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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