The Superior Therapeutic Properties of SOM230 Originate from Unique Structural Elements
| Autor: | Ian Lewis, Gisbert Weckbecker, Herbert A. Schmid, Steven W.J. Lamberts, Viktor Boerlin, Joost van der Hoek, Günter Bovermann, Lukas Oberer, Janos Pless, Nagarajan Chandramouli, Wilfried Bauer, Rainer Albert, Christian Bruns |
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| Jazyk: | German<br />English<br />French |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | CHIMIA, Vol 58, Iss 4 (2004) |
| Druh dokumentu: | article |
| ISSN: | 0009-4293 2673-2424 |
| DOI: | 10.2533/000942904777677902 |
| Popis: | A rational drug design approach involving transposition of functional groups from SRIF into a reduced size cyclohexapeptide template has led to the discovery of SOM230, a novel, stable cyclohexapeptide somatostatin mimic which exhibits unique high affinity binding to human somatostatin receptors (sst1-5). SOM230 has potent, long lasting inhibitory effects on growth hormone and insulin-like growth factor-1 release and is a promising development candidate currently under evaluation in phase II clinical trials. |
| Databáze: | Directory of Open Access Journals |
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