Cup-like acute myeloid leukemia: new disease or artificial phenomenon?
| Autor: | Frank P. Kroschinsky, Ulrike Schäkel, Rainer Fischer, Brigitte Mohr, Uta Oelschlaegel, Roland Repp, Markus Schaich, Silke Soucek, Gustavo Baretton, Gerhard Ehninger, Christian Thiede |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Haematologica, Vol 93, Iss 2 (2008) |
| Druh dokumentu: | article |
| ISSN: | 0390-6078 1592-8721 |
| DOI: | 10.3324/haematol.11669 |
| Popis: | We investigated cup-like nuclear morphology of acute myeloid leukemia blasts in 266 randomly selected patients and its association with hematologic findings, disease markers and outcome data. Cup-like acute myeloid leukemia was diagnosed in 55 patients (21%). It was associated with female sex, high white blood cell and blast cell counts, normal karyotype, and low CD34 and HLA-DR expression. Mutations of FLT3, NPM1 or both were detected in 84.9% compared with 58.1% in cases without this morphology (p=0.001). There was no influence on response to treatment or survival. Therefore, cup-like nuclear morphology is an indicator of normal karyotype and should guide more specific molecular analyses. |
| Databáze: | Directory of Open Access Journals |
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