Nanoparticle Albumin-Bound Paclitaxel- and/or Gemcitabine-Induced Scleroderma Accompanied by Acanthosis Nigricans-Like Skin Changes

Autor:	Sei-ichiro Motegi, Mai Ishikawa, Akiko Sekiguchi, Osamu Ishikawa
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	nanoparticle albumin-bound paclitaxel gemcitabine scleroderma acanthosis nigricans Dermatology RL1-803
Zdroj:	Case Reports in Dermatology, Vol 11, Iss 3, Pp 273-277 (2019)
Druh dokumentu:	article
ISSN:	1662-6567
DOI:	10.1159/000503271
Popis:	We herein present the first case of nanoparticle albumin-bound paclitaxel (nab-paclitaxel)- and/or gemcitabine-induced scleroderma accompanied by acanthosis nigricans-like skin changes in a 54-year-old Japanese male. He was diagnosed with pancreatic cancer and received 17 courses of nab-paclitaxel and gemcitabine chemotherapy. Edema and skin sclerosis in his legs appeared after the first and third course, respectively. Histological examination of the hyperkeratotic lesion of the ankle revealed hyperkeratosis, acanthosis, papillomatosis, increased number of melanocytes in the basal layer, and dermal fibrosis. Awareness of the clinical characteristics of nab-paclitaxel- and/or gemcitabine-induced scleroderma accompanied by acanthosis nigricans-like skin changes is important for dermatologists to establish an accurate diagnosis.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/90169cad0ded499da893f4ebedda02db Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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