Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle

Autor:	Fanqiang Bu, Mengnan Liu, Zixu Xie, Xinyu Chen, Guofeng Li, Xing Wang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	biofilm microenvironment biofilm-targeting material antibacterial Medicine Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceuticals, Vol 15, Iss 10, p 1253 (2022)
Druh dokumentu:	article
ISSN:	1424-8247
DOI:	10.3390/ph15101253
Popis:	Biofilm is a crucial virulence factor for microorganisms that causes chronic infection. After biofilm formation, the bacteria present improve drug tolerance and multifactorial defense mechanisms, which impose significant challenges for the use of antimicrobials. This indicates the urgent need for new targeted technologies and emerging therapeutic strategies. In this review, we focus on the current biofilm-targeting strategies and those under development, including targeting persistent cells, quorum quenching, and phage therapy. We emphasize biofilm-targeting technologies that are supported by blocking the biofilm life cycle, providing a theoretical basis for design of targeting technology that disrupts the biofilm and promotes practical application of antibacterial materials.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/90167b60a32344c8aebcd64ae43a1fd4 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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