Rare Case of Late-Onset Narcolepsy Type 1
| Autor: | Petra Kovalská, Simona Dostálová, Hana Machová, Petra Nytrová, Eszter Maurovich Horvat, Karel Šonka |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Case Reports in Neurology, Vol 12, Iss 3, Pp 428-432 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1662-680X 00051063 |
| DOI: | 10.1159/000510633 |
| Popis: | A 69-year-old male developed symptoms typical of the diagnosis of narcolepsy type 1 without any previous triggering events. First, daytime sleepiness occurred, soon followed by cataplexy. Nocturnal polysomnography revealed rapid eye movement (REM) sleep behavior disorder, a apnea-hypopnea index of 25.8 events/h, and no sleep-onset REM. Multiple Sleep Latency Test showed a mean sleep latency of 2.1 min and REM sleep in 3 tests. HLA DQB1*06:02 was positive and hypocretin-1 in cerebrospinal fluid unmeasurable. A treatment with 50 mg clomipramine controlled the cataplexy; excessive daytime sleepiness was sufficiently managed by repeated naps. The administration of 0.25 mg of clonazepam subjectively improved REM sleep behavior disorder. Bilevel Positive Airway Pressure improved the apnea-hypopnea index without important influence on sleepiness. Our unique case demonstrates that even elderly subjects can develop narcolepsy type 1. |
| Databáze: | Directory of Open Access Journals |
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