LPCAT2 controls chemoresistance in colorectal cancer

Autor:	Alexia Karen Cotte, Virginie Aires, François Ghiringhelli, Dominique Delmas
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	colorectal cancer chemoresistance immunogenic cell death lipid droplets lpcat2 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2018.1448245
Popis:	Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation.
Databáze:	Directory of Open Access Journals
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