Ultrasound-guided transbronchial cryobiopsy of mediastinal and hilar lesions: a multicenter pragmatic cohort study with real-world evidence

Autor: Thomas Gaisl, Silvia Ulrich, Maurice Roeder, Tsogyal D Latshang, Jürgen Hetzel, Carolin Steinack, Melanie Scarlett Mangold, Daniel P Franzen, Silvan M Vesenbeckh
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Druh dokumentu: article
ISSN: 2052-4439
DOI: 10.1136/bmjresp-2024-002617
Popis: Background Limited data exist on the reliability, efficacy and safety of ultrasound-guided transbronchial cryobiopsy for suspicious mediastinal and hilar lesions. This study shares findings from implementing this method and compares the results with those of the standard endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA).Methods Patients undergoing diagnostic bronchoscopy for mediastinal or hilar lesions in four Swiss centres were included. The study aims to assess the diagnostic yield and safety of EBUS-guided cryobiopsy compared with EBUS-TBNA. Tunnelling to the target lesion was performed using an electric needle knife (70.8%), a 19 G- (12.4%) or a 22 G needle (16.8%). Cryobiopsies were obtained with a freezing time of 4–7 s (18.2% with a 1.7 mm probe) or 6–10 s (81.8% with a 1.1 mm probe).Results Altogether, 137 patients were enrolled with a median follow-up of 89 days. The overall diagnostic yield was 56.2% for EBUS-TBNA and 91.2% for cryobiopsies (p
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