Growth factors, their receptors and down-stream signaling proteins in human tumors: from experiment to clinical practice

Autor:	E. S. Gershtein, N. E. Kushlinsky
Jazyk:	ruština
Rok vydání:	2015
Předmět:	growth factors epidermal growth factor receptors her2 / neu pi3k akt nf-κb targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Успехи молекулярной онкологии, Vol 1, Iss 1, Pp 27-35 (2015)
Druh dokumentu:	article
ISSN:	2313-805X 2413-3787
DOI:	10.17650/2313-805X.2014.1.1.27-35
Popis:	The basic contemporary data and the results of authors’ long-term personal research devoted to the role of auto / paracrine growth factors, their receptors and some down-stream signaling proteins (PI3K, Akt, NF-κB) in clinical course, prognosis and development of hormonal and drug sensitivity of various human tumors are reviewed. The data on the key targeted drugs suppressing various growth factor signaling pathways components are summarized with special attention to the criteria of assessment of individual sensitivity to these drugs including those based on modern molecular biologic technologies.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8ff8af3730ee47ed96596b39c2832ee2 Zobrazit plný text záznamu View record in DOAJ