Src-transformed cells hijack mitosis to extrude from the epithelium

Autor: Katarzyna A. Anton, Mihoko Kajita, Rika Narumi, Yasuyuki Fujita, Masazumi Tada
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-07163-4
Popis: Potentially cancerous cells undergo live apical extrusion from normal monolayers and vSrc expression induces this in zebrafish epithelia. Here, the authors show that vSrc coordinates cytokinetic ring formation, cell cycle progression, junctional integrity, cell survival and apicobasal polarity to induce extrusion of transformed cells.
Databáze: Directory of Open Access Journals