Analysis of Association between IL-17 gene rs2275913 Single Nucleotide Polymorphism and Chronic Hepatitis B Infection
| Autor: | H Tayefinasrabadi, SR Mohebbi, P Azimzadeh, B Hatami, Sh Kazemian, M Saeedi Niasar, A Sharifian, M Zali |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 20, Iss 1, Pp 42-36 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1561-4107 2251-7170 |
| Popis: | BACKGROUND AND OBJECTIVE: Hepatitis B disease is one of the main causes of inflammation and liver damage that can lead to chronic hepatitis B virus infection. Single nucleotide polymorphism in the cytokines gene can affect the host immune response. Interleukin 17 produced by Thelper17 cells has been shown to play a role in immune function in infectious and inflammatory diseases. This study was conducted to investigate the association between polymorphism in IL-17 gene (rs2275913) and chronic hepatitis B infection. METHODS: This case-control study was performed on 130 chronic patients as a case group and 130 healthy individuals as control. Patients with positive result of ELISA test for HBsAg and Anti-HBc Ab and control subjects with negative result of this test were enrolled. PCR-RFLP was used to genotype extracted DNA from blood samples. FINDINGS: The genotype frequencies of rs2275913 did not show significant difference between patients and control groups. Distribution of genotypes inpatients were, 40.8% GG, 41.5% AG, 17.7% AA and in control group were, 42.3% GG, 45.4% AG, 12.3% GG (p=0.469). CONCLUSION: The results of study showed no relation between IL-17 gene polymorphism rs2275913 and chronic HBV. |
| Databáze: | Directory of Open Access Journals |
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