Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity

Autor:	Ban-Feng Ruan, Wei-Wei Ge, Hui-Jie Cheng, Hua-Jian Xu, Qing-Shan Li, Xin-Hua Liu
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Resveratrol derivatives cinnamic ester anti-inflammatory NF-κB signaling pathway molecular docking Therapeutics. Pharmacology RM1-950
Zdroj:	Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1282-1290 (2017)
Druh dokumentu:	article
ISSN:	1475-6366 1475-6374 14756366
DOI:	10.1080/14756366.2017.1381090
Popis:	Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway.
Databáze:	Directory of Open Access Journals
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