4.8 INCREASED CARDIAC WORKLOAD IN THE UPRIGHT POSTURE IN MALE SUBJECTS: NON-INVASIVE HEMODYNAMICS IN MEN VERSUS WOMEN

Autor: Pauliina Kangas, Anna Tahvanainen, Antti Tikkakoski, Jenni Koskela, Marko Uitto, Jari Viik, Mika Kahonen, Tiit Koobi, Emeritus Jukka Mustonen, Ilkka Porsti
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Artery Research, Vol 16 (2016)
Druh dokumentu: article
ISSN: 1876-4401
DOI: 10.1016/j.artres.2016.10.027
Popis: Background: Men and women differ in the risk of cardiovascular disease, but the underlying mechanisms are not completely understood. We examined possible sex-related differences in supine and upright cardiovascular regulation. Methods: Hemodynamics were recorded from 167 men and 167 women of matching age (∼45 years) and body mass index (∼26.5 kg/m2) during passive head-up tilt. None had diabetes, cardiovascular disease other than hypertension, or antihypertensive medication. Whole-body impedance cardiography, tonometric radial blood pressure, and heart rate variability were analyzed. Results were adjusted for height, smoking, alcohol intake, mean arterial pressure, plasma lipids and glucose. Results: Supine hemodynamic differences were minor: lower heart rate (−4%) and higher stroke volume (+7.5%) in men than women (p55 years). Heart rate variability analyses showed higher low frequency to high frequency ratio in supine (p
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