| Autor: |
Bouchaud Olivier, Mühlberger Nikolai, Parola Philippe, Calleri Guido, Matteelli Alberto, Peyerl-Hoffmann Gabriele, Méchaï Frédéric, Gautret Philippe, Clerinx Jan, Kremsner Peter G, Jelinek Tomas, Kaiser Annette, Beltrame Anna, Schmid Matthias L, Kern Peter, Probst Meike, Bartoloni Alessandro, Weinke Thomas, Grobusch Martin P |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Malaria Journal, Vol 11, Iss 1, p 212 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1475-2875 |
| DOI: |
10.1186/1475-2875-11-212 |
| Popis: |
Abstract Background Malaria continues to be amongst the most frequent infectious diseases imported to Europe. Whilst European treatment guidelines are based on data from studies carried out in endemic areas, there is a paucity of original prospective treatment data. The objective was to summarize data on treatments to harmonize and optimize treatment for uncomplicated malaria in Europe. Methods A prospective observational multicentre study was conducted, assessing tolerance and efficacy of treatment regimens for imported uncomplicated falciparum malaria in adults amongst European centres of tropical and travel medicine. Results Between December 2003 and 2009, 504 patients were included in 16 centres from five European countries. Eighteen treatment regimens were reported, the top three being atovaquone-proguanil, mefloquine, and artemether-lumefantrine. Treatments significantly differed with respect to the occurrence of treatment changes (p = 0.005) and adverse events (p = 0.001), parasite and fever clearance times (p Conclusions This study highlights the heterogeneity of standards of care within Europe. A consensus discussion at European level is desirable to foster a standardized management of imported falciparum malaria. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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