| Autor: |
Gheorghe Borodi, Maria Olimpia Miclaus, Marieta Muresan-Pop, Alexandru Turza |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Crystals, Vol 14, Iss 6, p 483 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2073-4352 |
| DOI: |
10.3390/cryst14060483 |
| Popis: |
Oxymetholone [C21H32O3] and metribolone [C19H24O2] are synthetic anabolic-androgenic agents which are included in the steroid class. Their ability to form new solid forms and their possibility to be included in host-guest β-cyclodextrin complexes was explored. The recrystallization of the compounds in a wide variety of solvents was accomplished. Two oxymetholone polymorphs and one oxymetholone acetic acid solvate were obtained:, while metribolone is reported only in the starting form. Their crystal structures were elucidated using single-crystal X-ray diffraction and the energies of intermolecular interactions were analyzed. Moreover, oxymetholone also showed the ability to be complexed in a new form of oxymetholone-β-cyclodextrin complex. The materials were also investigated by powder X-ray diffraction, DSC/DTA/TGA analysis, and FT-IR spectroscopy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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