No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1

Autor: Albertas Navickas, Sébastien Chamois, Rénette Saint-Fort, Julien Henri, Claire Torchet, Lionel Benard
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-13991-9
Popis: In the No-Go decay mRNA surveillance pathway, mRNAs containing stalled ribosomes are cleaved by an endoribonuclease. Here the authors show the endonucleolytic cleavage on the artificial No-Go decay target mRNAs, revealing downstream decay process by Trl1 kinase and the 5′ to 3′ exonuclease Dxo1.
Databáze: Directory of Open Access Journals