Hepatitis E virus prevalence among blood donors in Wuhan urban agglomeration
| Autor: | Qin YU, Tingting XU, Lijie ZHANG, Lei ZHAO |
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| Jazyk: | čínština |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Zhongguo shuxue zazhi, Vol 37, Iss 1, Pp 21-25 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1004-549X 1004-549x 79210449 |
| DOI: | 10.13303/j.cjbt.issn.1004-549x.2024.01.004&lang=en |
| Popis: | Objective To investigate the prevalence of Hepatitis E virus (HEV) among blood donors in Wuhan urban agglomeration, aimed at providing data support for the development of HEV screening strategies for blood donors. Methods A total of 3 329 blood samples were collected from four centralized testing areas (Ezhou, Tianmen, Xiantao and Qianjiang) and screened at Wuhan Blood Center from January to December 2021. Among them, 2 737 were eligible blood samples with normal ALT (ALT normal group) and 592 were with elevated ALT (ALT elevated group). Enzyme linked immunosorbent assay (ELISA) was used to detect anti-HEV IgG, anti-HEV IgM and HEV-Ag, and Real-time PCR was used to perform single HEV RNA detection on blood samples with elevated ALT and normal ALT anti-HEV IgM+ blood samples. A two-sided Pearson’s chi-squared test or Fisher's exact test was used to evaluate the differences in the positive rates of anti-HEV IgG and anti-HEV IgM in different regions and ALT groups. Results The overall positive rates of anti-HEV IgG, anti-HEV IgM, and HEV-Ag in 3 329 blood samples from four regions were 21.63%, 1.29%, and 0%, respectively. There was a significant difference in the positive rates of anti-HEV IgG among blood donors in different regions (P |
| Databáze: | Directory of Open Access Journals |
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