Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase

Autor: Renato Antônio dos Santos Oliveira, Mayara Marques Carneiro da Silva, Carlos Eduardo Calzavara-Silva, Ana Maria Silva, Marli Tenório Cordeiro, Patrícia Muniz Mendes Freire de Moura, Paulo Neves Baptista Filho, Ernesto Torres de Azevedo Marques Júnior, Laura Helena Vega Gonzales Gil
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Memorias do Instituto Oswaldo Cruz, Vol 111, Iss 6, Pp 378-384 (2016)
Druh dokumentu: article
ISSN: 1678-8060
0074-0276
DOI: 10.1590/0074-02760150453
Popis: Dengue is an acute febrile disease caused by the mosquito-borne dengue virus (DENV) that according to clinical manifestations can be classified as asymptomatic, mild or severe dengue. Severe dengue cases have been associated with an unbalanced immune response characterised by an over secretion of inflammatory cytokines. In the present study we measured type I interferon (IFN-I) transcript and circulating levels in primary and secondary DENV infected patients. We observed that dengue fever (DF) and dengue haemorrhagic fever (DHF) patients express IFN-I differently. While DF and DHF patients express interferon-α similarly (52,71 ± 7,40 and 49,05 ± 7,70, respectively), IFN- β were associated with primary DHF patients. On the other hand, secondary DHF patients were not able to secrete large amounts of IFN- β which in turn may have influenced the high-level of viraemia. Our results suggest that, in patients from our cohort, infection by DENV serotype 3 elicits an innate response characterised by higher levels of IFN- β in the DHF patients with primary infection, which could contribute to control infection evidenced by the low-level of viraemia in these patients. The present findings may contribute to shed light in the role of innate immune response in dengue pathogenesis.
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