The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline
| Autor: | Sahar R. Fadhel, Najwa I. Abdulla, Intidhar D. Sulaiman |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Iraqi Journal of Pharmaceutical Sciences, Vol 25, Iss 1 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2521-3512 1683-3597 |
| DOI: | 10.31351/vol25iss1pp42-49 |
| Popis: | A new spectrophotometric method has been developed for the assay of olanzapine (OLN.) in pure and dosage forms. The method is based on the diazocoupling of (OLN.) with diazotized p-nitroaniline in alkaline medium to form a stable brown colored water-soluble azo dye with a maximum absorption at 405 nm. The variables that affect the completion of reaction have been carefully optimized. Beer’s law is obeyed over the concentration range of (0.5-45.0 μg.mL-1) with a molar absorptivity of 1.5777×104 L.mol-1.cm-1. The limit of detection was 0.3148 μg.mL-1 and Sandell’s sensitivity value was 0.0198 μg.cm-2. The proposed method has been applied successfully to the determination of olanzapine in tablet pharmaceutical preparations. Keywords: Spectrophotometry, Olanzapine, Diazotization, p-nitroaniline, tablet dosage form. |
| Databáze: | Directory of Open Access Journals |
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