Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells

Autor: Yaning Shi, Jennifer Kovacs-Nolan, Bo Jiang, Rong Tsao, Yoshinori Mine
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Journal of Functional Foods, Vol 11, Iss , Pp 571-580 (2014)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2014.08.017
Popis: Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO
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