Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels

Autor:	Jinyu Wang, Weibo Zhao, Haixiao Chen, An Qin, Peizhi Zhu
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Methotrexate Chondroitin sulfate Self-assembly Nanogels Anti-tumor Nanomedicine Materials of engineering and construction. Mechanics of materials TA401-492
Zdroj:	Nanoscale Research Letters, Vol 12, Iss 1, Pp 1-8 (2017)
Druh dokumentu:	article
ISSN:	1931-7573 1556-276X
DOI:	10.1186/s11671-017-2324-1
Popis:	Abstract Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side effects of MTX. Due to their CD44 binding property, chondroitin sulfate-drug conjugates could be a promising and efficient platform for improving the solubility of sparingly soluble drug molecules as well as targeted delivery to cancer cells and tumor tissues.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8f98fa4be45347d8a38c43cc07c92b4a Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ