Changes in the Composition of the Gut Microbiota and the Blood Transcriptome in Preterm Infants at Less than 29 Weeks Gestation Diagnosed with Bronchopulmonary Dysplasia

Autor: Feargal J. Ryan, Damian P. Drew, Chloe Douglas, Lex E. X. Leong, Max Moldovan, Miriam Lynn, Naomi Fink, Anastasia Sribnaia, Irmeli Penttila, Andrew J. McPhee, Carmel T. Collins, Maria Makrides, Robert A. Gibson, Geraint B. Rogers, David J. Lynn
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: mSystems, Vol 4, Iss 5 (2019)
Druh dokumentu: article
ISSN: 2379-5077
DOI: 10.1128/mSystems.00484-19
Popis: ABSTRACT Bronchopulmonary dysplasia (BPD) is a common chronic lung condition in preterm infants that results in abnormal lung development and leads to considerable morbidity and mortality, making BPD one of the most common complications of preterm birth. We employed RNA sequencing and 16S rRNA gene sequencing to profile gene expression in blood and the composition of the fecal microbiota in infants born at
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