Characterization of low level viraemia in HIV-infected patients receiving boosted protease inhibitor-based antiretroviral regimens
| Autor: | Francesca Ferretti, Nicola E. Mackie, Gurmit Kaur Jagjit Singh, Julie Fox, Steve Kaye, Myra O. McClure, Graham Taylor, Marta Boffito |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | HIV Research & Clinical Practice, Vol 20, Iss 4-5, Pp 107-110 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2578-7470 25787489 |
| DOI: | 10.1080/25787489.2020.1716159 |
| Popis: | To understand the pathogenesis of low level viraemia (LLV) in HIV-infected patients on boosted protease inhibitors (PI/b), we enrolled 34 subjects with a median HIV-RNA 79 copies/mL and followed them for 15 months. Samples for next generation sequencing were collected at three time-points. Two showed resistance-associated mutations (RAMs) in the protease gene, while 95–100% had RAMs in the gag gene, which evolved in approximately a quarter of subjects, suggesting a potential clinical role of these kind of mutations. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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