No harm from angiotensin-converting enzyme inhibitors or angiotensin receptor inhibitors in patients with COVID-19. Results of a prospective study on a hospital-based cohort
| Autor: | Gian Paolo Anzola, Clara Bartolaminelli, Gina Alessandra Gregorini, Chiara Coazzoli, Francesca Gatti, Alessandra Mora, Dimitrios Charalampakis, Andrea Palmigiano, Michele De Simone, Alice Comini, Erica Dellaglio, Salvatore Cassetti, Maurizio Chiesa, Francesca Spedini, Patrizia d'Ottavi, Maria Cristina Savio |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Italian Journal of Medicine, Vol 14, Iss 3 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1877-9344 1877-9352 |
| DOI: | 10.4081/itjm.2020.1313 |
| Popis: | This study aims to assess the effect of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor inhibitors (ARBs) on the course of COVID-19. It is a prospective study on 221 (M/F ratio= 143/78, mean age 72±13) consecutive hypertensive patients with COVID-19: 76 (34.4%) treated with ACEIs, 63 (28.5%) with ARBs and 82 (37.1%) with antihypertensives OTHER than ACEIs or ARBs. They were all followed up until discharge or death. BAD outcome was defined as the need for invasive mechanical ventilation or death. The three classes of medication were well balanced for confounding variables. BAD outcome was overall recorded in 63/221 (28%) patients, in 20/76 (26%) of ACEI, in 17/63 (27%) of ARB and in 26/82 (32%) of OTHER users, with no statistically significant difference in any comparison. These findings refute the hypothesis that treatment with ACEIs or ARBs may negatively affect the course of COVID-19. |
| Databáze: | Directory of Open Access Journals |
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