| Autor: |
Beytullah Çakal, Macit Kalçık, Ahmet Güner, Mahmut Yesin, Mustafa Ozan Gürsoy, Sabahattin Gündüz, Süleyman Karakoyun, Emrah Bayam, Semih Kalkan, Mehmet Özkan |
| Jazyk: |
English<br />Turkish |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Türk Kardiyoloji Derneği Arşivi, Vol 48, Iss 6, Pp 566-575 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1016-5169 |
| DOI: |
10.5543/tkda.2020.23621 |
| Popis: |
Objective: Prosthetic valve thrombosis (PVT) is a serious complication among patients with prosthetic heart valves. Thrombolytic therapy (TT) is now widely used as first-line treatment for PVT. Endothelial dysfunction has previously been reported in patients with PVT. The aim of this study was to investigate the changes in endothelial function soon after TT in PVT patients. Methods: The study group included 85 patients with PVT [female: 53 (62.3%); age: 48.7+-13.9 years] who were evaluated prospectively before and shortly after TT. All of the patients were evaluated using transthoracic and transesophageal echocardiography. TT was administered in all cases with a low-dose, ultra-slow infusion regimen. Endothelial function was evaluated using a noninvasive measurement of flow-mediated dilatation (FMD) of the brachial artery during reactive hyperemia. Results: The study population included 38 (44.7%) obstructive and 47 (55.3%) non-obstructive PVT patients. The obstructive PVT patients had lower baseline FMD values than the non-obstructive PVT group (5.31+-0.76% vs. 5.87+-0.84%; p=0.003). TT was successful in 79 patients (92.9%). FMD was significantly increased in the successfully thrombolyzed patients after TT (5.65+-0.86% vs. 7.13+-1.26%; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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