| Autor: |
Benjamin M. Ellingson, Jingwen Yao, Catalina Raymond, Ararat Chakhoyan, Kasra Khatibi, Noriko Salamon, J. Pablo Villablanca, Ina Wanner, Courtney R. Real, Azim Laiwalla, David L. McArthur, Martin M. Monti, David A. Hovda, Paul M. Vespa |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
NeuroImage: Clinical, Vol 22, Iss , Pp - (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2019.101736 |
| Popis: |
Cerebral acidosis is a consequence of secondary injury mechanisms following traumatic brain injury (TBI), including excitotoxicity and ischemia, with potentially significant clinical implications. However, there remains an unmet clinical need for technology for non-invasive, high resolution pH imaging of human TBI for studying metabolic changes following injury. The current study examined 17 patients with TBI and 20 healthy controls using amine chemical exchange saturation transfer echoplanar imaging (CEST EPI), a novel pH-weighted molecular MR imaging technique, on a clinical 3T MR scanner. Results showed significantly elevated pH-weighted image contrast (MTRasym at 3 ppm) in areas of T2 hyperintensity or edema (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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