Age of onset correlates with clinical characteristics and prognostic outcomes in neuromyelitis optica spectrum disorder

Autor: Yacen Hu, Qiying Sun, Fang Yi, Lingyan Yao, Yun Tian, Haiyun Tang, Mengchuan Luo, Nina Xie, Zhiqin Wang, Xinxin Liao, Lin Zhou, Hongwei Xu, Yafang Zhou
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Immunology, Vol 13 (2022)
Druh dokumentu: article
ISSN: 1664-3224
DOI: 10.3389/fimmu.2022.1056944
Popis: ObjectiveNeuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease preferentially affects the optic nerve and the spinal cord. The first attack usually occurs in the third or fourth decade, though patients with disease onset in the fifties or later are not uncommon. This study aimed to investigate the clinical characteristics and prognosis in patients with different age of onset and to explore the correlations between age of onset and clinical characteristics and prognostic outcomes.MethodWe retrospectively reviewed the medical records of 298 NMOSD patients diagnosed according to the 2015 updated version of diagnostic criteria. Patients were divided into early-onset NMOSD (EO-NMOSD) (
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