| Autor: |
Raju Cheerlavancha, Ahmed Ahmed, Yun Cheuk Leung, Aggie Lawer, Qing-Quan Liu, Marina Cagnes, Hee-Chan Jang, Xiang-Guo Hu, Luke Hunter |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2316-2325 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1860-5397 |
| DOI: |
10.3762/bjoc.13.228 |
| Popis: |
Backbone-extended amino acids have a variety of potential applications in peptide and protein science, particularly if the geometry of the amino acid is controllable. Here we describe the synthesis of δ-amino acids that contain three vicinal C–F bonds positioned along the backbone. The ultimately successful synthetic approach emerged through the investigation of several methods based on both electrophilic and nucleophilic fluorination chemistry. We show that different diastereoisomers of this fluorinated δ-amino acid adopt distinct conformations in solution, suggesting that these molecules might have value as shape-controlled building blocks for future applications in peptide science. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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