Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study

Autor: Harriet Lomholt-Welch, Andrew J Morrow, Robert Sykes, Merna Saleh, Baryab Zahra, Alasdair MacIntosh, Anna Kamdar, Catherine Bagot, Hannah K Bayes, Kevin G Blyth, Heerajnarain Bulluck, David Carrick, Colin Church, David Corcoran, Iain Findlay, Vivienne B Gibson, Lynsey Gillespie, Douglas Grieve, Pauline Hall Barrientos, Antonia Ho, Ninian N Lang, David J Lowe, Vera Lennie, Peter W Macfarlane, Kaitlin J Mayne, Patrick B Mark, Alex McConnachie, Ross McGeoch, Sabrina Nordin, Alexander Payne, Alastair J Rankin, Keith Robertson, Nicola Ryan, Giles Roditi, Naveed Sattar, David Stobo, Sarah Allwood-Spiers, Rhian M Touyz, Gruschen Veldtman, Sarah Weeden, Robin Weir, Stuart Watkins, Paul Welsh, Kenneth Mangion, Colin Berry
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Heart and Mind, Vol 7, Iss 4, Pp 235-245 (2023)
Druh dokumentu: article
ISSN: 2468-6476
2468-6484
DOI: 10.4103/hm.HM-D-23-00037
Popis: Background: The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain. Objectives: This article will investigate the associations between baseline mental health status and disease trajectory following COVID-19 hospitalization, which may have implications for practice and future research. Methods: The Chief Scientist Office Cardiovascular and Pulmonary Imaging in severe acute respiratory syndrome (SARS) COVID-19 study is a prospective, observational, multicenter, longitudinal, secondary care cohort study that assessed the time-course of multi-organ injury in posthospital survivors of COVID-19. Patients were assessed in-hospital, at 28–60 days after discharge and in the longer term using electronic health record linkage. Results: One hundred and fifty-two patients (mean ± standard deviation [SD] age 54.3 ± 11.8 years, 43% female, 40% most socio-economically deprived quintile, 33% history of mental health history) were enrolled and had mental health serially assessed using the Patient Health Questionnaire-4 (PHQ-4) questionnaire. Fifty-three (35%) had PHQ-4 score of 6–12 consistent with moderate-severe symptoms of anxiety or depression and this was associated with diagnostic criteria for myocarditis (P = 0.0498). Moderate-severe symptoms of anxiety or depression were positively associated with higher perception of illness, lower health-related quality of life (HRQoL), and poorer physical function. The mean (SD) duration of follow-up after hospital discharge was 428 (86) days (range, 290–627 days). PHQ-4 score was not associated with clinical outcomes at follow-up. Conclusions: In patients who have been hospitalized with COVID-19, moderate-severe symptoms of anxiety or depression were associated with myocarditis, worse HRQoL, higher perception of illness, and lower levels of physical function. Public Registration: ClinicalTrials.gov identifier is NCT04403607.
Databáze: Directory of Open Access Journals
Externí odkaz: