EPIDEMIOLOGY AND SURVIVAL OF PATIENTS WITH MALIGNANT TUMORS OF CONNECTIVE AND SOFT TISSUE

Autor: V. M. Merabishvili, O. F. Chepik, E. N. Merabishvili
Jazyk: ruština
Rok vydání: 2016
Předmět:
Zdroj: Сибирский онкологический журнал, Vol 1, Iss 3, Pp 5-12 (2016)
Druh dokumentu: article
ISSN: 1814-4861
2312-3168
Popis: Introduction. Malignant tumors of connective and soft tissue are met relatively rare, although in general in Russia each year more than 1.500 new cases are registered. On five administrative territories of Russia during a year there are recorded less than 5 new cases of malignant tumors of connective and soft tissue (Yamal-Nenets A.R. – 4; Tuva Republic – 0, Magadan Region – 3; Chukotka A.R. – 0; Jewish A.R. – 4. More seldom data on these patients’ survival are published. Purpose of study. To estimate dynamics of incidence of malignant tumors of connective and soft tissue on the basis of public reporting, to calculate the index accuracy and observed and relative survival rates by histological forms, including sarcomas. Material and methods. To perform a detailed study there were selected, for two periods of observation, respectively 1054 patients (1995–2001) and 919 patients (2002–2008). Estimation of survival was carried out using software, which had been developed together with Ltd. «Novel» (Director – T.L.Tsvetkova, Ph.D.). results of study. The most typical incidence rate for of malignant tumors of connective and soft tissue (S47, 49) that are presented by cancer registries of different countries is from 1.5 to 2.5 0/ in men and 1.5–2.0 0/ in women. Dynamics of morbidity of the Russian population, Moscow and St. Petersburg indicates that the level of standardized incidence rates is in the range of 2.0 0/ in men and within 1.5 0/ in women. The mortality rate in 2013 was respectively for men and women in Russia in total 1.7 0/ and 1.13 0/ , in Moscow – 1.42 0/ and 1.24 0/ , in St. Petersburg – 1.88 0/ and 1.26 0/ . The index accuracy for both sexes in Russia is 0.88, in Moscow – 1.2; in St. Petersburg – 1.4. This index should be used for the site of these diseases with high fatality. According to official data a one-year lethality of patients with tumors of connective and soft tissue in 2013 was 20.1 %, and for all malignant tumors – 25.3 %, however the index accuracy for all malignant tumors was equal to 0.72, and for malignant tumors of connective and soft tissue – 0.88. That is in 5 of 8 federal districts the index accuracy is 1 or more, testifies significant undercount of patients with malignant tumors of connective and soft tissue. conclusion. The study allowed determining, despite relatively low rates of morbidity and mortality from malignant tumors of connective and soft tissue, there was revealed a significant undercount of primary cases. In a number of federal districts morbidity exceeds morbidity. Kaposi’s sarcoma is a tiny fraction of this group of tumors. The main part of patients with malignant tumors of connective and soft tissue is for C49 column «Malignant tumors of other types of connective and soft tissue». In basic part of patients with malignant tumors of connective and soft tissue there has been established positive dynamics of a 5-year observed and relative survival but this level is lower than the European average. Among sarcomas all malignant tumors of connective and soft tissue the best indicator of survival is for liposarcoma (>70 %), then for leiomyosarcoma (>40 %), and the least for sarcoma with undefined diagnosis.
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